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Parthasarathy, R.
- Blood Glucose Lowering Potential of Chinese Violet (Asystasia gangetica (L.) T. Anderson) in Normal and Streptozotocin Induced Diabetic Rats
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Authors
Affiliations
1 Department of Biotechnology, School of Life Sciences, Karpagam University, Coimbatore-641021, Tamil Nadu, IN
2 Bioprocess Lab, Department of Botany, Government Arts College, Coimbatore, Tamil Nadu-641018, IN
1 Department of Biotechnology, School of Life Sciences, Karpagam University, Coimbatore-641021, Tamil Nadu, IN
2 Bioprocess Lab, Department of Botany, Government Arts College, Coimbatore, Tamil Nadu-641018, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 6, No 4 (2014), Pagination: 170-175Abstract
Objective: The present study was undertaken to investigate the glucose reducing level by Asystasia gangetica flowers with various doses (125, 250 and 500 mg/kg bw) in normal and streptozotocin induced diabetic rats. Methods: Acute and sub-acute toxicity of A. gangetica was evaluated in rats with various doses and its and serum parameters were analyzed. Diabetes was induced by giving streptozotocin (45 mg/kg bw) to the rats and after conformation of diabetes, A. gangetica flower ethanol extract (AGFEE) was administrated to the normal and diabetic rats for a period of 14 days. Body weight and glucose levels were determined after 7th and 14th day of the study. Glucose tolerance test was also carried out after administration of glucose at the rate of 2 g/kg bw till 14th day. Results: The LD50 of extract found to be higher than 2000 mg/kg bw and the extract did not show any significant changes in serum parameters. In blood glucose reducing activity the three doses showed significant lowering glucose levels, when compared with each doses at the dose of 250 mg/kg bw the AGFEE showed maximum activity. In diabetic control rats there was a significant elevation in blood glucose levels and reduction in body weight was produced and continued till the end of the study. No alterations were found in control and extract alone treated rats. Results showed AGFEE had exhibited significant hypoglycemic (glucose lowering) activity. Conclusion: Present in vivo model indicating that the plant extract contain active principle compound for the management of hyperglycemia.Keywords
Asystasia gangetica Flowers, Streptozotocin, Glucose Tolerance, Hyperglycemia.
References
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- In vitro Antioxidant Activity of Bark and Leaf of Thespesia populnea
Abstract Views :190 |
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Authors
Affiliations
1 Himachal Institute of Pharmacy Education and Research Naudan, Bela, Hamirpur, Himachal Pradesh-177033, IN
2 Himachal Institute of Pharmacy Education and Research, Naudan, Bela, Hamirpur, Himachal Pradesh-177033, IN
1 Himachal Institute of Pharmacy Education and Research Naudan, Bela, Hamirpur, Himachal Pradesh-177033, IN
2 Himachal Institute of Pharmacy Education and Research, Naudan, Bela, Hamirpur, Himachal Pradesh-177033, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 8, No 1 (2016), Pagination: 1-4Abstract
The free radical scavenging activity of Thespesia populnea bark (TPBE) and leaves (TPLE) has been studied using the methanolic extracts. In vitro antioxidant potential of leaves and stem bark were evaluated in three different models viz superoxide radical scavenging activity, lipid peroxide radical scavenging activity and hydroxyl radical scavenging activity. The two methanolic extract were prepared with different concentration from a maximum of 400μg to minimum of 50μg. All extract have different level of antioxidant property. In comparison, the antioxidant scavenging activity in hydroxyl radical was higher, In super oxide radical was moderate and lesser in lipid peroxide radical. These observations confirm that methanolic extract of Thespesia populnea bark and leaf have different polyphenolic constituent and its importance in antioxidant activity.Keywords
Antioxidant, Thespesia populnea Leaf, Thespesia populnea Bark.- Pharmacognostical studies on Thespesia populnea Leaf
Abstract Views :202 |
PDF Views:0
Authors
Affiliations
1 Himachal Institute of Pharmacy Education and Research, Naudan, Bela, Hamirpur, Himachal Pradesh -177033, IN
1 Himachal Institute of Pharmacy Education and Research, Naudan, Bela, Hamirpur, Himachal Pradesh -177033, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 8, No 1 (2016), Pagination: 16-20Abstract
Thespesia populnea is a reputed ever green tree belonging to the family Malvaceae; commonly known as Indian tulip tree. The plant is distributed tropical regions and coastal forest in India. It is well known and all the parts are used in traditional system of medicine. The plant has been used as astringent, antibacterial, hepatoprotective, haemostatic, anti-diarroheal and anti-inflammatory. The scientific parameter is necessary to identify the exact plant material and to find its quality and purity. The present study deals with various pharmacognostical examinations like organoleptic or macroscopical characters, microscopical or anatomical studies, physical evaluation and preliminary phytochemical screening of various successive extracts were carried out and the parameters were reported. These studies indicated the possible information for correct identification and standardization of this plant material.Keywords
Thespesia populnea, Leaf Macroscopy, Leaf Microscopy.- Pharmacognostical Studies on Thespesia populnea Bark
Abstract Views :167 |
PDF Views:0
Authors
Affiliations
1 Bharath University, Selaiyur, Chennai-600 073, Tamil Nadu, IN
2 Srinivasa Murthi Drug Research Institute for Ayurveda and Siddha, Chennai-600 109, Tamil Nadu, IN
3 Bharath University, Selaiyur, Chennai-600 073, Tamil Nadu., IN
1 Bharath University, Selaiyur, Chennai-600 073, Tamil Nadu, IN
2 Srinivasa Murthi Drug Research Institute for Ayurveda and Siddha, Chennai-600 109, Tamil Nadu, IN
3 Bharath University, Selaiyur, Chennai-600 073, Tamil Nadu., IN